Simple Spectrophotometric Methods for Determination of Tolterodine Tartrate in Pharmaceutical Forms

Simple, fast and reproducible methods were developed for the determination of Tolterodine tartrate (TOL), the first method (method A) was based on the oxidation of the drug using permanganate in acidic medium in the presence of methylene blue dye and estimation of (TOL) by measuring the absorbance of the residual amount of methylene blue dye at 600 nm, in (method B) the drug amount was estimated by measuring the residual amount of permanganate which absorbs at 540 nm in basic medium. The calibration of the methods using beer's law was investigated in the ranges of 12-60 and 5-50 μg/ml and Limits of detection of 3.6 and 2.2 μg/ml for method A and method B respectively.